Monday, April 24, 2017

Cancer Cure Research Papers


 What is cancer?

http://pathology.jhu.edu/pc/BasicTypes1.php?area=ba
The word cancer is derived from the Latin word for crab  because cancers are often very irregularly shaped, and because, like a  crab, they "grab on and don't let go." The term cancer specifically  refers to a new growth which has the ability to invade surrounding  tissues, metastasize (spread to other organs) and which may eventually  lead to the patient's death if untreated.  The terms tumor and cancer are sometimes used  interchangeably which can be misleading. A tumor is not necessarily a  cancer. The word tumor simply refers to a mass. For example, a  collection of fluid would meet the definition of a tumor. A cancer is a  particularly threatening type of tumor. It is helpful to keep these  distinctions clear when discussing a possible cancer diagnosis.  
Neoplasm- A neoplasm is an abnormal new  growth of cells. The cells in a neoplasm usually grow more rapidly than  normal cells and will continue to grow if not treated. As they grow,  neoplasms can impinge upon and damage adjacent structures. The term  neoplasm can refer to benign (usually curable) or malignant (cancerous)  growths.   
Tumor- A tumor is a commonly used, but  non-specific, term for a neoplasm. The word tumor simply refers to a  mass. This is a general term that can refer to benign (generally  harmless) or malignant (cancerous) growths.   
Benign tumor- Benign tumors are  non-malignant/non-cancerous tumor. A benign tumor is usually localized,  and does not spread to other parts of the body. Most benign tumors  respond well to treatment. However, if left untreated, some benign  tumors can grow large and lead to serious disease because of their size.  Benign tumors can also mimic malignant tumors, and so for this reason  are sometimes treated.  
Malignant tumor- Malignant tumors are cancerous  growths. They are often resistant to treatment, may spread to other  parts of the body and they sometimes recur after they were removed.   
Cancer- A cancer is another word for a malignant tumor (a malignant neoplasm). 

Cancer Cures

I use ResearchGate for Research like this just because you do not have to pay to read their papers if they are the ones hosting it. Sometime they will redirect you to other Research Journals,but any paper they host is free. Most of the cures are based on the findings of FAAH Inhibitors, and the actions of Fatty Acids in the brain, and Fatty Acid is the FA in FAAH. The H in FAAH is Hydroxylase, FAAH is an enzyme that messes with the Hydrogen atoms hanging off of Fatty Acids. And an FAAH Inhibitor inhibits that action, allowing the Hydrogen to go unscathed. The cures are not themselves FAAH Inhibitors, but have come along within the scope of the same research as FAAH Inhibitors. The reason Fatty Acids are important is because they create new molecules in your brain that attach to receptors like the CB1 and CB2 receptors, and the CB2 receptor is the receptor that most effectively helps cure or prevent Tumors and Cancer.

https://www.researchgate.net/publication/236250821_The_endocannabinoid_signaling_system_in_cancer
 "Changes in lipid metabolism are intimately related to cancer. Several  classes of bioactive lipids play roles in the regulation of signaling  pathways involved in neoplastic transformation and tumor growth and  progression. The endocannabinoid system, comprising lipid-derived  endocannabinoids, their G-protein-coupled receptors (GPCRs), and the  enzymes for their metabolism, is emerging as a promising therapeutic  target in cancer... A significant number of studies have been performed to clarify the biological role of the ECS, its regulatory functions in health and disease, and the potential of its pharmacological exploitation. The ECS comprises two GPCRs, CB1 and CB2"

Colon Cancer
https://www.researchgate.net/publication/235780162_Coconut_Oil_Chemistry_Production_and_Its_Applications_-_A_Review
"Saturated fatty acids can be used to: boost the immune system, for weight management, as antimicrobials, to support the structure of gut mucosa, and as dietary adjuncts in cases of chronic degenerative disease, such as cardiovascular disease, liver disease and cancer."

https://www.researchgate.net/publication/13668627_Dietary_Fish_Oil_Suppresses_Human_Colon_Tumour_Growth_in_Athymic_Mice
"Dietary fish oil (FO) has been shown to lower  the  incidence  of  chemically  induced  colon cancer in  rats compared with  saturated  fats or oils rich in n-6 PUFAs."


General Cancer
https://www.researchgate.net/publication/24427518_Cannabinoids_in_the_treatment_of_cancer

https://www.researchgate.net/publication/232719860_Cannabinoids_and_Omega-36_Endocannabinoids_as_Cell_Death_and_Anticancer_Modulators
"Similarities between effects of cannabinoids-endocannabinoids, omega-3  LCPUFA and CLAs/CLnAs as anti-inflammatory, antiangiogenic,  anti-invasive anti-cancer agents indicate common signalling pathways.  Evidence in vivo and in vitro shows EPA and DHA can form  endocannabinoids that: (i) are ligands for CB(1/2) receptors and  possibly TRPV-1, (ii) have non-receptor mediated bioactivity, (iii)  induce cell cycle arrest, (iii) increase autophagy and apoptosis, and  (iv) augment chemotherapeutic actions in vitro."

https://www.researchgate.net/publication/258114758_Recent_Development_of_CB2_Selective_and_Peripheral_CB1CB2_Cannabinoid_Receptor_Ligands
"...can be achieved by either increasing the selectivity of the ligands for  the CB2 receptor or by developing peripherally restricted CB1/CB2  ligands. A vast number of structurally diverse CB2 ligands have been  developed during the past 3 years, stemming from the screening hits,  which are further optimized towards lead compounds and drug candidates.  Some of CB2 ligands may ultimately enter into clinical use as pain  relief, anticancer, or antipruritic agents. "

Lung Cancer

https://www.researchgate.net/publication/51924103_Cannabidiol_inhibits_lung_cancer_cell_invasion_and_metastasis_via_intercellular_adhesion_molecule-1
"This study investigates the role of intercellular adhesion molecule-1  (ICAM-1) within this action. In the lung cancer cell lines A549, H358,  and H460, cannabidiol (CBD; 0.001-3 μM) elicited concentration-dependent  ICAM-1 up-regulation compared to vehicle via cannabinoid receptors,  transient receptor potential vanilloid 1, and p42/44 mitogen-activated  protein kinase. Up-regulation of ICAM-1 mRNA by CBD in A549 was 4-fold  at 3 μM, with significant effects already evident at 0.01 μM. ICAM-1  induction became significant after 2 h, whereas significant TIMP-1 mRNA  increases were observed only after 48 h. Inhibition of ICAM-1 by  antibody or siRNA approaches reversed the anti-invasive and  TIMP-1-upregulating action of CBD and the likewise ICAM-1-inducing  cannabinoids Δ(9)-tetrahydrocannabinol and R(+)-methanandamide when  compared to isotype or nonsilencing siRNA controls. ICAM-1-dependent  anti-invasive cannabinoid effects were confirmed in primary tumor cells  from a lung cancer patient. In athymic nude mice, CBD elicited a 2.6-  and 3.0-fold increase of ICAM-1 and TIMP-1 protein in A549 xenografts,  as compared to vehicle-treated animals, and an antimetastatic effect  that was fully reversed by a neutralizing antibody against ICAM-1 [%  metastatic lung nodules vs. isotype control (100%): 47.7% for CBD +  isotype antibody and 106.6% for CBD + ICAM-1 antibody]. Overall, our  data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1  induction and subsequent decreased cancer cell invasiveness."

Breast Cancer

https://www.researchgate.net/publication/38065500_Synthetic_cannabinoid_receptor_agonists_inhibit_tumor_growth_and_metastasis_of_breast_cancer
"CB1 and CB2 are overexpressed in primary human breast tumors compared  with normal breast tissue. We have also observed that the breast cancer  cell lines MDA-MB231, MDA-MB231-luc, and MDA-MB468 express CB1 and CB2  receptors."

Gliomas (Brain Cancer)

https://www.researchgate.net/publication/5892365_Cannabinoids_and_Gliomas
"...inhibit the growth of different types of tumor cells, including glioma cells, in laboratory animals. They do so by modulating key cell  signaling pathways, mostly the endoplasmic reticulum stress response,  thereby inducing antitumoral actions such as the apoptotic death of  tumor cells and the inhibition of tumor angiogenesis."

Melanoma (Skin Cancer)

https://www.researchgate.net/publication/221975902_Revisiting_CB1_Receptor_as_Drug_Target_in_Human_Melanoma
"Previous studies have indicated the antitumoral effect of human  melanocytes, human melanoma cell lines expressing CB1 receptor (CB1),  and of the peritumoral administration of endocannabinoids. In the  present study, we systematically screened several human melanoma cell  lines for the expression of CNR1 and demonstrated transcription of the  authentic gene. The product of CNR1, the CB1 protein, was found  localized to the cell membrane as well as to the cytoskeleton. Further,  the studied human melanoma cell lines expressed functional CB1 since  physiological and synthetic ligands, anandamide (AEA), Met-F-AEA, ACEA  and AM251 showed a wide range of biological effects in vitro, for  example anti-proliferative, proapoptotic and anti-migratory. More  importantly, our studies revealed that systemic administration of a  stable CB1 agonist, ACEA, into SCID mice specifically inhibited liver  colonization of human melanoma cells. Since therapeutic options for  melanoma patients are still very limited, the endocannabinoid-CB1  receptor system may offer a novel target."


FAAH Inhibitors

https://www.researchgate.net/publication/40835209_FAAH_and_MAGL_inhibitors_Therapeutic_opportunities_from_regulating_endocannabinoid_levels
"Two major enzymes have been cloned and investigated thoroughly: fatty  acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).  Inhibitors of these enzymes have demonstrated therapeutic benefit in  animal models of several disorders, including neuropathic pain, anxiety  and inflammatory bowel diseases, as well as against the proliferation  and migration of cancer cells. This review describes the major  biochemical properties of FAAH and MAGL, and the design and  pharmacological properties of inhibitors of these enzymes."

1 comment:

  1. I had absolutely no symptoms or warnings that I had cancer. In March 2007 I suddenly felt like I had diarrhea but it was all blood and I went to the ER. I bled profusely through the rectum for an hour or so until they got it stopped. The doctor did a colonoscopy and found a stage II cancer, i was devastated when my doctor broke the sad news to me because i thought that was the end for me because i have heard so much news about how cancer have stolen away the lives of patients. With time i developed a 'belly' when all my life my abdomen was flat. I was still in my search for a cure after undergoing chemo and radiation thrice Until a friend of mine directed me to doctor Amber and advised me to try alternative medicine, which i did because then my doctor was no longer helpful at all and i had given up on myself. I got the herbal medicine which was relatively small in size, which i took for 10 weeks. For the past two and half years, I have had two additional colonoscopies and two CT scans, plus blood tests. So far, no recurrence, i am indeed really grafeful to GOD and Dr.Amber who stood by me and made all this happen through his medicine. Never give up hope and if you find yourself in the situation i was some years ago you can also contact him too via his personal email drambermurray@gmail.com

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